'iPhone 4S' and iPad 3 Coming in Late October?

Macotakara reports that it has received information indicating that Apple will be introducing the iPad 3 and "iPhone 4S" sometime early next month, with availability set for "late October". The source offered no information, however, on plans for the iPhone 5, although rumors have suggested that Apple will introduce both a revamped iPhone 5 and tweaked iPhone 4 next month.


According to sources, iPhone 4S which is based on iPhone 4(CDMA) and new iPad will be started produce since 1st week in September and will be shipped in late October.

The "iPhone 4S" name is an unofficial one that has been used in a variety of reports to refer to a new iPhone based largely on and appearing nearly identical to the current iPhone 4, but offering upgraded internal components. What has come to be known as the iPhone 5 is a more thorough redesign which has surfaced in case designs reportedly based on leaked design specs. 

There had been some confusion about whether Apple would be releasing an "iPhone 4S" or "iPhone 5" this year, with some suggesting that the confusion stemmed from Apple testing iPhone 5 components within iPhone 4 enclosures for secrecy. But others have claimed that Apple will indeed be introducing both the iPhone 5 and a tweaked iPhone 4 as rumors of a low-cost iPhone have continued to swirl.

 Apple has of course traditionally kept its older models around as entry-level options, as evidenced Apple's continued sale of an 8 GB iPhone 3GS model, but the volume of rumors suggest that Apple may be doing a bit more tweaking to its low-end offerings this time around. Such low-cost models are said to be key for penetrating the prepaid markets prevalent in a number of large countries around the world.

Macotakara has offered some accurate information in the past, and notably was the first source to pinpoint some of the features of the iPad 2 as case designs began leaking out. A number of potential dates for a media event introducing the iPhone 5 and perhaps the iPad 3 have been suggested, with early reports of a September timeframe being countered early last week with a report from All Things Digital claiming that the device won't be available until October. The latest rumor has, however, claimed a September 7th media event, although an iPhone 5 introduction at that time to be followed with a launch as far off as late October would be outside Apple's usual gap between introduction and availability.

‘Breakthrough’ Immunotherapy Method Cures Advanced Cancer

Killer T-Cell

A breakthrough therapy to modify T-cells into potent tumor-killing agents wiped out leukemia in three patients and allowed two of them to stay cancer-free for a year, US researchers said Wednesday.

The findings are the first to show how gene transfer therapy can create specialized T-cells, which guard the body from infection, that attack cancerous tumors in advanced cases of chronic lymphocytic leukemia (CLL).

The technique helped three elderly male patients who otherwise had little hope of survival, said the research published simultaneously in the New England Journal of Medicine and Science Translational Medicine.

Further studies are needed, but the advances offer hope to people who suffer from other cancer types such as ovarian, lung, myeloma and melanoma.

"Within three weeks, the tumors had been blown away, in a way that was much more violent than we ever expected," said senior author Carl June of the Abramson Cancer Center of the University of Pennsylvania.

"It worked much better than we thought it would."

Scientists removed a sample of the patients' T-cells and genetically modified them to attack all cells that express a certain kind of protein, CD19, which includes tumor cells.

They also engineered the T-cells to start triggering other T-cells to multiply as soon as they attached to a cancer cell, bringing on a faster death for the tumor but avoiding the side-effects of cancer drugs.

"We saw at least a 1,000-fold increase in the number of modified T-cells in each of the patients. Drugs don't do that," said June, describing the infused T-cells as "serial killers."

"On average, each infused T-cell led to the killing of thousands of tumor cells -- and overall, destroyed at least two pounds of tumor in each patient."

One patient's case, described in the New England Journal of Medicine, involved a 64-year-old man whose blood and marrow were "replete with tumor cells."

He saw little change for the first two weeks after treatment, but then started experiencing nausea, chills and fever. Test showed he was undergoing a huge rise in T-cell count. By day 28, his blood showed no evidence of leukemia.

A 65-year-old patient saw similar results, with no trace of tumor after a year, but the 77-year-old patient saw a slight recurrence of cancer after he was treated with steroids. However his tumor load remains far from what it was before the treatment.

"Most of what I do is treat patients with no other options, with a very, very risky therapy with the intent to cure them," said co-principal investigator David Porter.

"This approach has the potential to do the same thing, but in a safer manner."

Bone marrow transplants are typically the only treatment for leukemia patients, but they carry a minimum 20 percent risk of dying from the procedure and cure rates hover at around 50 percent.

It remains unknown how long the treatment may keep cancer at bay.

"The doctors have found evidence that months after infusion, the new cells had multiplied and were capable of continuing their seek-and-destroy mission against cancerous cells throughout the patients' bodies," said the study.

Chronic lymphocytic leukemia is the second most common type of adult leukemia after acute myeloid leukemia, according to the National Cancer Institute.

The researchers intend to study similar approaches in children whose leukemia has resisted standard treatment.

They are also looking to see if the approach could target non-Hodgkin's lymphoma and acute lymphocytic leukemia, mesothelioma cancer cells, ovarian and pancreatic cancer cells.

Assassin's Creed 4: Revelations Beta Release Details for PSN/PS3

Assassin's Creed Revelations Multiplayer Beta, the early test drive version of the 4th episode of the historical, award-winning science fiction video game is about to Released by Ubisoft, exclusively for Sony Playstation Network, on September 03, 2011.


Assassin's Creed Revelations Multiplayer Beta will be equiped with:

• 3 Maps: Knight’s Hospital, Antioch, Constantinople
• 4 Modes: Wanted, Manhunt, Deathmatch, Artifact Assault
• 9 Characters: The Sentinel, The Vanguard, The Guardian, The Vizier, The Thespian, The Deacon, The Bombadier, The Trickster, The Champion

PlayStation Plus Subscribers and Ubisoft UPlay Service Members will have an exclusive chance to download and play new Assassin's Creed 4 Revelations Multiplayer beta on PS3, for the holiday season, this September 03 to 11. UPlay members will receive their Beta invite via email.

Assassin's Creed 4 Revelations Multiplayer beta is promised to bring a whole bunch of new and updated tools of the trade for players to test out.

Assassin's Creed 4: Revelations multiplayer beta Gameplay
Assassin's Creed 4 Revelations multiplayer beta Gameplay will include a little of the old and the new, bringing back favorite modes and abilities, while throwing out a few of the new ones in the process. Perks, streaks, and loss bonuses have all been redesigned to include things like "Animus Hacking" – where, after a kill streak of six, a player can rain down arrows and kill all Templars on the map.

Assassin's Creed 4: Revelations multiplayer beta Maps
Speaking of maps, the playing field will be freshened up and available at outset to allow players to take one of nine possible assassin’s out for a stroll. Comprised of three new maps – Knight’s Hospital, Antioch, and Constantinople – the new spaces will give a whole list of areas for characters to run, jump, dive, and hide.

Assassin's Creed 4: Revelations multiplayer beta Modes
Though be careful, as the four possible modes have been tweaked since Assassin’s Creed: Brotherhood, which means they will no doubt be a bit different. Bringing back Wanted and Manhunt, the long-awaited Deathmatch is making an appearance as well. Another new mode, Artifact Assault, asks teams to try and steal the opposing player’s artifact in a "Capture the flag" style of play. The catch is however; players are allowed to kill only when they are in their territory – adding a new level of complexity.

To get away and make those kills, a select few abilities will be available, including Smoke, Morph, Fire Crackers, Throwing Knives and more. There are a few new ones as well, including a Tripwire Bomb and Closure ,which captures enemies or a target, allowing you to step in for the kill (or whatever other action is required).

Assassin's Creed 4: Revelations Release Date for Public
Assassin’s Creed 4: Revelations Release Date for Xbox 360, PS3 and PC is set to November 15, 2011.

NASA Picks Seven Commercial Spaceships for the Next Generation of Suborbital Science Missions

Virgin SpaceShip

The new post-shuttle NASA has said it aims to work more cooperatively with private space industry and outside sources of innovation in writing the next chapter in space exploration and science, and the agency is putting its money where its mouth is. After selecting 30 future technology proposals for funding earlier this week, NASA has now inked a number of much larger contracts with seven private space companies--including Virgin Galactic--to integrate and fly various technology payloads aboard their suborbital spacecraft.

We single out Virgin because its SpaceShipTwo is the furthest spacecraft along, development-wise, which means it could soon be ferrying scientific payloads into suborbital space, making it the first commercial company to take that role over from NASA in the post-shuttle era. SpaceShipTwo is already undergoing flight tests and could begin commercial operation as soon as next year.

That’s a big deal, because it’s a stepping stone toward fulfilling NASA’s vision of opening up space to more scientists and technology developers, and doing it on someone else’s less-expensive spacecraft. And Virgin isn’t the only company with a dog in this hunt: the other companies splitting the $10 million in contracts are Armadillo Aerospace, Near Space Corp., Masten Space Systems, Up Aerospace Inc., Whittinghill Aerospace LLC, and XCOR.

Many of these companies are looking to carry tourists into space, but the overarching idea of the Flight Opportunities Program (that’s the NASA funding initiative) is to cultivate a variety of ways for researchers to get their experiments--manned or unmanned--into space as well. There’s a lot of benefit to be spread around in doing so.

For one, it opens up suborbital space to groups that couldn’t afford it or simply couldn’t make the manifest on prior NASA missions (which were quite selective and pricey per pound of cargo). It also supports the private space industry by opening up another revenue stream for the Virgins and XCORs and Mastens of the world. But perhaps most importantly for NASA it means a proliferation in space science and technology development, and technologies that fall out of this program just might become part of NASA’s next-gen space transportation model.

Source: SPACE

New Drug Can Treat Almost Any Viral Infection

In the left set, rhinovirus (the common cold virus) kills untreated human cells (lower left), whereas DRACO has no toxicity in uninfected cells (upper right) and cures an infected cell population (lower right). Similarly, in the right set, dengue hemorrhagic fever virus kills untreated monkey cells (lower left), whereas DRACO has no toxicity in uninfected cells (upper right) and cures an infected cell population (lower right). MIT

A new broad-spectrum treatment for viruses could be as effective as antibiotics fighting bacteria, MIT researchers report. The method uses cells’ own defense systems to induce invaded cells to commit suicide, preventing the spread of the virus. In lab tests, the new drug completely cured mice that had been infected with influenza.

Viruses work by inserting themselves into a cell and hijacking its machinery for its own use. The invaded cell then creates more copies of the virus, which involves creating long strings of double-stranded RNA — which contains the virus’ genetic material, like DNA contains ours.

When the virus is done copying itself, its hostage cell usually dies, from the virus bursting through its walls (lysis), changes to the cell’s outer membrane, and from apoptosis, or programmed cell death.

Human cells have plenty of defenses against viral invasion, including proteins that attach to the double-stranded RNA, preventing the virus from replicating itself after successful invasion.

This new drug therapy combines those dsRNA proteins with a protein that induces apoptosis. It’s called a DRACO, Double-stranded RNA Activated Caspase Oligomerizer.

When one end of the DRACO binds to dsRNA, it signals the other end of the DRACO to induce cell suicide, an MIT News article explains. In this way, the cell is killed before the virus can take over and eventually kill it anyway. If there is no dsRNA, the healthy cells are left alone.

“In theory, it should work against all viruses,” said Todd Rider, a senior staff scientist at MIT’s Lincoln Laboratory who invented the new technology.

A handful of drugs can target specific viruses by interfering with their replication process, through addition of modified DNA building blocks or the blocking of enzymes the viruses need to stimulate the replication process. But viruses are wily bugs, and they can evolve to resist these treatments.

The DRACO therapy could be effective because it targets the host cell, not just the virus.

Rider and colleagues are testing DRACO against more viruses in mice, according to MIT. Rider hopes to license the technology for trials in larger animals and for eventual human clinical trials, too.

Source: MIT News

Apple Becomes the World’s Most Valuable Company Crossing Exxon Mobile

The world’s leading smartphone manufacturer and vendor, Apple Inc., is now the world’s most valuable company surpassing Exxon Mobil Corporation.

Earlier today, Apple’s shares were trading at $367 which made it briefly past Exxon Mobil, with a total worth of more than $341 billion.

Two months ago, Apple was about $50 billion less in worth than the oil and gas corporation. But after reporting record sales (in the last few weeks) of two of the most popular gadgets i.e. iPad and iPhone, it has managed to take over the top position.

On the other hand, Exxon Mobil has seen a steeper decline as oil prices have fallen over the past few days. For how long Apple will be able to keep the top spot? We will have to wait and see where the market settles at the end of the week to find that out.

[via Mashable]

Apple Sued Over 'Fast Booting' Patent which Links To LG

Patently Apple reports that Apple has been hit with a new patent lawsuit targeting "fast booting" used in OS X, a method of utilizing boot configuration information from earlier booting processes to speed the system startup process.


The lawsuit specifically states that Apple's OS X violates "at least Claim 1" of the OSS patent. The claim in question reads as follows: 

"A method for fast booting a computer system, comprising the steps of: A. performing a power on self test (POST) of basic input output system (BIOS) when the system is powered on or reset is requested; B. checking whether a boot configuration information including a system booting state which was created while executing a previous normal booting process exists or not; C. storing the boot configuration information from execution of the POST operation before loading a graphic interface (GUI) program, based on the checking result; and D. loading the graphic user interface (GUI) program."


What is most interesting about the patent and associated lawsuit is that the patent application was initially filed back in 1999 and assigned to LG Electronics. LG is of course a competitor to Apple in the smartphone market, but also serves as a supplier to Apple, primarily through its LG Display arm.

It is unclear, however, whether LG still has any stake in the patent in question, as the assignment on the patent has changed hands multiple times dating back to 2004. LG initially passed the patent off to a company known as Microconnect LLC, but the patent was subsequently passed along to firms by the names of Protimus Technologies LLC and ANPA Inc while also being reissued once along the way. The patent lawsuit has been brought by a Florida-based company called Operating Systems Solutions LLC, which appears to be a previously-unknown entity that may have been created specifically for the purposes of the lawsuit.

Apple is of course no stranger to patent and other types of lawsuits, not only engaging in high-profile disputes with major competitors but also both taking on and being targeted by smaller firms. And while this latest lawsuit may simply be a case of a small patent holding firm seeking to capitalize on its holdings, the patent's historical ties to LG naturally lead to questions about whether yet another of Apple's major competitors is playing a role in the ever-increasing legal entanglements for Apple.

Earth Has a Ring of Anti-Protons !

While it's not as visually cool as what Saturn has going for it, this is still an important development, even if we can't technically "see" the ring with our primitive Earthling eyes.

According to New Scientist, this anti-proton ring joins the previously discovered positron cloud that's also circling the Earth like an invisible shield. Ironically, the anti-protons are 2,000 times more massive than their positron counterparts, but were discovered second. Both are trapped in a donut-like ring called the Van Allen radiation belt that's held in place by the planet's magnetic field.

In the distant future, a spacecraft designed to use anti-protons (or other types of antimatter) as a fuel source could tap into this ring to top off its tanks and head out into the void, said Alessandro Bruno, a member of the University of Rome Tor Vergata team that confirmed the anti-proton area's existence.

Between July 2006 and December 2008, PAMELA detected 28 antiprotons trapped in spiralling orbits around the magnetic field lines sprouting from the Earth’s south pole (Astrophysical Journal Letters, DOI: 10.1088/2041-8205/737/2/l29). PAMELA samples only a small part of the inner radiation belt, but antiprotons are probably trapped throughout it. “We are talking about of billions of particles,” says team member Francesco Cafagna from the University of Bari in Italy.

Twenty-eight antiprotons sounds like nothing, really. But that’s actually a pretty substantial quantity, and verifies the hypothesized but not-yet-evident theory that such a ring might exist. So it looks like now all we need are those super-efficient rockets.


Source:New Scientist [image: New Scientist]

Apple iOS 4.3.5 Jailbreak: iPad, iPod Touch and iPhone 4.3.5 Jailbreak

Apple iOS 4.3.5 was released alongwith fixes for some previous Vulnerabilities in the new mobile operating system.



However, thanks to MuscluNerd, a iPhone Dev Team member, who confirmed on twitter that the new Apple iOS 4.3.5 Jailbreak is still a possibility on all devices like iPad, iPod Touch and iPhone (except the iPad 2) just by pointing the tool at the 4.3.4 IPSW:

Warning: Those of you, who are relying on a carrier unlock must stay away from Redsn0w Jailbreak.

Since Apple patched comex’s exploit in Apple iOS 4.3.4, this will be a Tethered iOS 4.3.5 Jailbreak. It is still recommended to stick with iOS 4.3.3 for an Untethered Jailbreak.

How to Tethered iPad, iPod Touch and iPhone 4.3.5 Jailbreak

First of all select and downlaod the appropriate program applicable to your device from the given options:

• Download iOS 4.3.5 and iOS 4.3.4 for iPhone, iPod Touch and iPad.
• Download Redsn0w 0.9.8b4 for Windows
Download Redsn0w 0.9.8b4 for Mac Download iTunes 10.4 for Mac and Windows

Now please follow these step by step instructions given here under:
Step 1: Start Redsn0w Apple iOS 4.3.5 Jailbreak program, browse for the iOS 4.3.4 firmware file (NOT the 4.3.5) that you downloaded above and point it towards Redsn0w.

Step 2: Once Redsn0w is done with recognizing the firmware file, click Next. Then check the 'Install Cydia' box and leave other options as it is for now. Once done, click Next.

Step 3: Now just follow Redsn0w, it will ask you to shut down your device and plug it in to the computer. Once plugged with computer, follow the onscreen instructions and then click Next to continue.

Step 4: RedSn0w will now guide you on how to put your device in DFU mode. Follow the instructions carefully till your device get’s into DFU mode. Follow these simple steps to put your Device into DFU Mode:

• First of all,Press and Hold the sleep button for 2 seconds.
• While holding the sleepbutton,Press the Home button for 10 seconds.
• Now release the sleep button but continue Holding the home button for about 15 seconds.

Step 5: One in DFU mode your iPhone will restart, Now, just wait while Redsn0w gets installed and jailbreaks your device. Once finished your iPhone, iPad or iPod touch will restart automatically.

Troubleshooting:
Any Windows users seeing 'Waiting for reboot' for too long (more than 20 seconds or so), please try 'shaking' the JB process by unplugging then replugging your USB cable (while letting redsn0w continue to run). Also, try using a USB port 'closer' to your computer (as opposed to on your monitor or behind another hub).


Apple iOS 4.3.5 Jailbreak on iPad, iPod Touch and iPhone 4/3Gs
Here is a video tutorial for Apple iOS 4.3.5 Jailbreak on iPad, iPod Touch 4/3Gs for iPhone 4.3.5 Jailbreak using RedSn0w 0.9.8b: